Dosage Forms & Strengths
powder for injection
• 15unit
• 30unit
Squamous Cell Carcinoma
0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks
Hodgkin's Disease, Non-Hodgkin's Lymphoma
Administer test dose of 1-2 units of bleomycin before first 1-2 doses; monitor vital signs q15min; wait 1 hour minimum before administering remainder of dose; if no acute reaction observe, may administer regular dosage schedule
0.25 to 0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks; reduce to maintenance dose of 1 unit qDay or 5 unit qWeek IV/IM after 50% response
Testicular Carcinoma
0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks
Pleural Sclerosing
60 unit in 50-100 mL as single instillation; may repeat dose at intervals of several days if fluid continues to accumulate (mix in 50-100 mL or NS); may add lidocaine 100-200 mg to reduce local discomfort
Elderly: May limit dose to 40 unit/m²
Pancreatic Cancer (Orphan)
Treatment of pancreatic cancer
Orphan indication sponsors
• Genetronics, Inc; 11199 Sorrento Valley Rd; San Diego, CA 92121-1334
• CIRJ Company Ltd; 1800 Loma Vista St; Pasadena, CA 91004
Renal Impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 40-50 mL/min: 70% of normal dose
CrCl 30-40 mL/min: 60% of normal dose
CrCl 20-30 mL/min: 55% normal dose
CrCl 10-20 mL/min: 45% normal dose
CrCl 5-10 mL/min: 40% normal dose
Hepatic Impairment
Dose adjustment not necessary
Monitor
Chest X-ray q1-2Weeks
Administration
In lymphoma patients, give first 2 doses at 1-2 units to test for anaphylactoid reaction
Limit lifetime dose to <400 units because of risk of pulmonary fibrosis
Low ADRs w/intrapleural administration
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Bleomycin is used to treat cancer. It works by slowing or stopping the growth of cancer cells. It Used in the treatment of squamous cell cancers, melanoma, sarcoma, testicular and ovarian cancer.
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Bleomycin solution for injection use, safety information, warnings and side effects, indications and usage, Interactions, dosage, patient information, adverse reactions and clinical pharmacology.
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This section displays common question about Bleomycin Injection.
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Bleomycin is used to treat cancer. It works by slowing or stopping the growth of cancer cells. This medication may also be used to control the build-up of fluid around the lungs (pleural effusion) caused by tumors that have spread to the lungs.
Click here for Download pdf of patient informationDosage Forms & Strengths powder for injection 15unit 30unit Squamous Cell Carcinoma 0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks
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Read MoreA dream for new world Anchored in India and committed to its traditional values of leadership with trust, the Taj Pharma Group is spreading its footprint globally through excellence and innovation.Taj Pahrma