Bleomycin Powder For Solution For Injection

Dosage Forms & Strengths

powder for injection

• 15unit

• 30unit

Squamous Cell Carcinoma

0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks

Hodgkin's Disease, Non-Hodgkin's Lymphoma

Administer test dose of 1-2 units of bleomycin before first 1-2 doses; monitor vital signs q15min; wait 1 hour minimum before administering remainder of dose; if no acute reaction observe, may administer regular dosage schedule

0.25 to 0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks; reduce to maintenance dose of 1 unit qDay or 5 unit qWeek IV/IM after 50% response

Testicular Carcinoma

0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks

Pleural Sclerosing

60 unit in 50-100 mL as single instillation; may repeat dose at intervals of several days if fluid continues to accumulate (mix in 50-100 mL or NS); may add lidocaine 100-200 mg to reduce local discomfort

Elderly: May limit dose to 40 unit/m²

Pancreatic Cancer (Orphan)

Treatment of pancreatic cancer

Orphan indication sponsors

• Genetronics, Inc; 11199 Sorrento Valley Rd; San Diego, CA 92121-1334

• CIRJ Company Ltd; 1800 Loma Vista St; Pasadena, CA 91004

Renal Impairment

CrCl >50 mL/min: Dose adjustment not necessary

CrCl 40-50 mL/min: 70% of normal dose

CrCl 30-40 mL/min: 60% of normal dose

CrCl 20-30 mL/min: 55% normal dose

CrCl 10-20 mL/min: 45% normal dose

CrCl 5-10 mL/min: 40% normal dose

Hepatic Impairment

Dose adjustment not necessary

Monitor

Chest X-ray q1-2Weeks

Administration

In lymphoma patients, give first 2 doses at 1-2 units to test for anaphylactoid reaction

Limit lifetime dose to <400 units because of risk of pulmonary fibrosis

Low ADRs w/intrapleural administration

Click here for Download pdf of patient information
Click here for Download pdf of prescribing information

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Product Summary

Bleomycin is used to treat cancer. It works by slowing or stopping the growth of cancer cells. It Used in the treatment of squamous cell cancers, melanoma, sarcoma, testicular and ovarian cancer.

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Frequently Asked Question

This section displays common question about Bleomycin Injection.

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Bleomycin Solution For Injection

How to use Bleomycin / Drug Interactions

Know more Bleomycin Solution for Injection

Dosing & Uses

Dosage Forms & Strengths powder for injection 15unit 30unit Squamous Cell Carcinoma 0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks

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Adverse Effects

>10% Mucocutaneous toxicity including rash, erythema, hyperpigmentation, urticaria (>50%) Febrile reactions, acute (25-50%)

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Pharmacology

Mechanism of Action Glycopeptide antibiotic; inhibits DNA, RNA, protein synthesis in G2, M phases Pharmacokinetics Half-Life: 2 hr

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